Calicheamicin CAS 108212-75-5

Cur síos ar an Táirge:

Ainm Táirge: Calicheamicin CAS NÍL: 108212-75-5

Comhchiallaigh:

gáma1(I);

Calicheamicin 1I;

Gáma Calicheamicin1;

Airíonna Fisiceacha Ceimiceacha:

Dealramh: Púdar

Measúnacht : Níos mó ná nó cothrom le 99.0 faoin gcéad

Density: 1.57±0.1 g/cm3(Predicted)

Alfa: D26 -124 céim (c=0.98 faoin gcéad , EtOH)

Pka: 7.13±0.60(Predicted)

The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin 1 being the most notable. It was isolated originally in the mid-1980s from the chalky soil, or "calichi pits", located in Kerrville, Texas. The sample was collected by a scientist working for Lederle Labs. It is extremely toxic to all cells and, in 2000, a CD33 antigen-targeted immunoconjugate N-acetyl dimethyl hydrazide calicheamicin was developed and marketed as targeted therapy against the non-solid tumor cancer acute myeloid leukemia (AML). Calicheamicin 1 and the related enediyne esperamicin are the two of the most potent antitumor agents known.

Calicheamicins are a series of enediyne antitumor antibiotics originally isolated from the bacterium Micromonospora echinospora. They exert high cytotoxicity and have been applied in tumor therapies for over a decade-- a CD33 antigen-targeted immuno-conjugate: N-acetyl dimethyl hydrazide calicheamicin, was developed as a targeted therapy for non-solid tumor cancer acute myeloid leukemia (AML). Calicheamicin has several derivatives with different chemical modifications, among which 1 is the most well-characterized. Calicheamicin 1 contains an aglycon consisting of a bicycle tridec-9-ene-2,6-diyne system with a labile methyl trisulfide group and an aryltetrasaccharide chain. Calicheamicins also contain enediyne moieties that are structurally similar to other enediynes, such as esperamicins, neocarzinostatin, and kedarcidin, etc. After reduction by cellular thiols, the calicheamicin enediyne moieties rearrange to produce a 1, 4-benzenoid diradical.

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Clibeanna Te: calicheamicin cas 108212-75-5, monaróirí, soláthraithe, monarcha, a cheannach, i stoc

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